Related Experiment Video
Updated: Jul 16, 2026
Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
Proliferative activity of cells in mouse thymus and spleen under different diurnal regimens of interleukin-2
I G Kovshik1, A N Silkov, S V Sennikov
1Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Abstract:
Circadian variations in spontaneous and concanavalin A-stimulated proliferation of mouse thymocytes and splenocytes were studied after administration of recombinant interleukin-2 at different times of day. Differences were revealed in the effect of morning and evening treatment with the cytokine. The time of injection corresponded to various phases of the natural circadian rhythm of endogenous interleukin-2 production, which probably contributes to diurnal differences in the influence of this cytokine.
