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Updated: Jul 16, 2026

Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates
Published on: May 9, 2016
Surrogacy theory and models of convoluted organic systems
1BioLingua Research Inc, Gaithersburg, MD 20886, USA. akk@blingua.org
Abstract:
The theory of surrogacy is briefly outlined as one of the conceptual foundations of systems biology that has been developed for the last 30 years in the context of Hertz-Rosen modeling relationship. Conceptual foundations of modeling convoluted (biologically complex) systems are briefly reviewed and discussed in terms of current and future research in systems biology. New as well as older results that pertain to the concepts of modeling relationship, sequence of surrogacies, cascade of representations, complementarity, analogy, metaphor, and epistemic time are presented together with a classification of models in a cascade. Examples of anticipated future applications of surrogacy theory in life sciences are briefly discussed.
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