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Related Experiment Video

Updated: Jul 16, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Ophthalmic surgery in prion diseases.

Tsuyoshi Hamaguchi¹, Moeko Noguchi-Shinohara, Yosikazu Nakamura

¹Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Emerging Infectious Diseases

|March 21, 2007

Summary

Infectious prion protein transmission occurred in 1.8% of patients undergoing ophthalmic surgery due to incomplete sterilization of surgical instruments. Ophthalmologists should consider prion diseases in visual disturbances and utilize disposable instruments to prevent prion spread.

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Area of Science:

Ophthalmology
Infectious Diseases
Neurology

Background:

Prion diseases are transmissible neurodegenerative disorders.
Ophthalmic surgery involves delicate instruments that can potentially transmit infectious agents.
Incomplete sterilization poses a risk for prion disease transmission.

Purpose of the Study:

To investigate the link between ophthalmic surgery and prion disease onset.
To assess the sterilization practices of surgical instruments in relation to prion disease.
To raise awareness among ophthalmologists regarding prion disease transmission risks.

Main Methods:

Retrospective analysis of 597 patients.
Identification of patients who underwent ophthalmic surgery around the onset of prion disease.
Review of surgical instrument sterilization protocols.

Main Results:

Eleven (1.8%) of 597 patients had ophthalmic surgery within one month before or after prion disease onset.
Surgical instruments were incompletely sterilized to eliminate infectious prion protein.
This suggests a potential route of prion transmission via surgical instruments.

Conclusions:

Ophthalmic surgery may be a potential route for prion disease transmission.
Incomplete sterilization of surgical instruments is a significant risk factor.
Ophthalmologists must be vigilant for prion diseases and prioritize disposable instruments.