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Polyamines and DNA methylation in childhood leukaemia

R G Schipper1, L P van den Heuvel, A A J Verhofstad

  • 1Department of Pathology, University Medical Centre Nijmegen, 6500 HB, Nijmegen, The Netherlands. raymond.schipper@wur.nl

Biochemical Society Transactions
|March 21, 2007
PubMed
Summary

Combining 6-mercaptopurine (6-MP) and methotrexate (MTX) with polyamine metabolism inhibitors shows synergistic effects against leukemia cells. This approach offers potential for treating patients resistant to standard purine metabolism inhibitors.

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