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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

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Reducing the availability of polyamines for a developing tumour.

¹Department of Biomedicine, University of Bergen, Jonas Liesvei 91, N-5009 Bergen, Norway. ian.pryme@biomed.uib.no

Biochemical Society Transactions

|March 21, 2007

Summary

Tumor growth increases demand for polyamines, essential molecules for cell growth. Manipulating dietary polyamines in mice can impact tumor growth by altering nutrient availability.

Area of Science:

Biochemistry
Physiology
Oncology

Background:

Mammals require nutrients and energy molecules for growth and metabolic needs, distributed by regulatory processes involving hormones and growth factors.
Organ nutrient partitioning is influenced by stress, nutrient scarcity, infection, and tumor growth.
The intestine, with high metabolic activity, competes with tumors for nutrients, and polyamine demand rises during tumor progression.

Purpose of the Study:

To investigate the impact of dietary polyamine manipulation on tumor growth.
To explore an alternative strategy for controlling tumor polyamine supply.

Main Methods:

Administered phytohaemagglutinin lectin in the diet to mice.
Induced dose-dependent growth and polyamine accumulation in the small intestine.

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Main Results:

Phytohaemagglutinin induced reversible small intestine growth and significant polyamine accumulation in intestinal epithelia.
This dietary intervention alters the availability of exogenous polyamines.

Conclusions:

Dietary manipulation of polyamines offers a novel approach to influence tumor growth.
Reducing exogenous polyamine availability to tumors by altering intestinal polyamine pools is a potential therapeutic strategy.