Related Experiment Video

Updated: Jul 16, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Daily blood pressure control is not sufficient to regress cardiac hypertrophy and dysfunction: a bi-ventricular

Mustafa Balal1, Mevlut Koc, Saime Paydas

  • 1Division of Nephrology, Department of Internal Medicine, School of Medicine, Cukurova University, Balcali-Adana, Turkey.

Nephrology (Carlton, Vic.)
|March 21, 2007
PubMed

Insights

Hypertension significantly increases cardiovascular risk in renal transplant recipients (RTxr). Controlling daytime blood pressure alone is insufficient; monitoring and managing night-time blood pressure is crucial for reducing cardiovascular risk in RTxr.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Hypertension is a primary driver of cardiovascular complications and allograft dysfunction.
  • This study investigates blood pressure and cardiac function in renal transplant recipients (RTxr) and dialysis patients.

Purpose of the Study:

  • To determine the relationship between 24-hour blood pressure levels and left ventricular mass index (LVMI).
  • To assess bi-ventricular tissue Doppler echocardiographic measurements in RTxr and dialysis patients.

Main Methods:

  • A cross-sectional study involving 32 non-diabetic RTxr (GI) and 18 end-stage renal disease dialysis patients (GII).
  • Evaluated daytime and night-time blood pressures, blood pressure loads, LVMI, and bi-ventricular Em/Am ratios via tissue Doppler echocardiography.

Main Results:

  • No significant differences were observed in age, gender, or daytime/night-time blood pressure and loads between GI and GII.
  • LVMI and bi-ventricular diastolic dysfunction (Em/Am ratios) did not show regression after renal transplantation.
  • Mean night-time systolic blood pressure loads were 4.92% in RTxr and 6.10% in dialysis patients.

Conclusions:

  • Left ventricular mass index and bi-ventricular diastolic dysfunction persist post-renal transplantation.
  • Effective reduction of cardiovascular risk in RTxr necessitates control of both daytime and night-time blood pressure and loads.
  • Ambulatory blood pressure monitoring and tissue Doppler echocardiography are recommended for RTxr monitoring.
Abstract

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...