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Levetiracetam prophylaxis in pediatric migraine--an open-label study
Ann Pakalnis1, Donna Kring, Lisa Meier
1Department of Neurology, Children's Hospital, Columbus, OH 43205, USA.
Background:
Migraine is common in the pediatric population. Levetiracetam, an anti-epileptic drug, has shown some efficacy in small prospective adult headache studies.
Methods:
We prospectively evaluated levetiracetam in an open-label study in 20 pediatric migraine patients to assess tolerability and efficacy.
Results:
Eighteen of 20 patients had significant reduction in headache frequency. PedMIDAS showed significant decrease in disability scores, side effects were minimal (mild behavioral changes).
Conclusion:
Levetiracetam had some efficacy in reducing migraine frequency and disability. Further larger studies are warranted, possibly utilizing a placebo-controlled design.
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