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Updated: Jul 16, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
Published on: January 4, 2017
[Connections between bone marrow and mesenchyme of the middle ear]
Jaime Rafael Whyte Orozco1, Ana Isabel Cisneros Gimeno, Raúl Pérez Sanz
1Departamento de Anatomía e Histología Humanas, Universidad de Zaragoza, Zaragoza, España. jwhyte@unizar.es
Objective:
To investigate the presence of connections between the bone marrow of the ossicles and the mesenchyme that fills the future tympanic cavity.
Material And Methods:
Ninety temporal bones from embryos and foetuses were examined, selecting 15 aged between 20th to 30th weeks of development, to show connections between ossicle marrow and mesenchyme.
Results:
The connections are transitory and appear in the malleus and the incus between 20th to 24th weeks of development, while in the stapes appear later, being between 24th to 28th weeks.
Conclusions:
These connections may have an important role in the phagocytosis of the mesenchymal remains and join in the detritus elimination mechanisms produced during the regression.
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