Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion changes in patients with systemic lupus erythematosus.

Lijuan Zhang1, Melanie Harrison, Linda A Heier

  • 1Department of Radiology, Weill Medical College, Cornell University, New York, NY 10021, USA.

Magnetic Resonance Imaging
|March 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry.

Journal of Alzheimer's disease : JAD·2025
Same author

Discriminant analysis using MRI asymmetry indices and cognitive scores of women with temporal lobe epilepsy or schizophrenia.

Neuroradiology·2024
Same author

A Macro-Structural Dispersion Characteristic of Brain White Matter and Its Application to Bipolar Disorder.

IEEE transactions on bio-medical engineering·2020
Same author

Investigation of superior longitudinal fasciculus fiber complexity in recent onset psychosis.

Progress in neuro-psychopharmacology & biological psychiatry·2017
Same author

Differential medial temporal lobe morphometric predictors of item- and relational-encoded memories in healthy individuals and in individuals with mild cognitive impairment and Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)·2017
Same author

The impact of systemic lupus erythematosus on women's sexual functioning: A systematic review and meta-analysis.

Medicine·2017

Diffusion tensor imaging detects early brain changes in systemic lupus erythematosus (SLE) patients, even with normal MRI scans. This quantitative analysis can identify preclinical central nervous system involvement and monitor disease progression.

Area of Science:

  • Neuroimaging
  • Radiology
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease.
  • Neuropsychiatric manifestations are a significant concern in SLE.
  • Routine MRI often shows nonspecific or negative findings in neuropsychiatric SLE.

Purpose of the Study:

  • To explore the utility of diffusion tensor imaging (DTI) in diagnosing SLE.
  • To identify early brain changes in SLE patients using DTI.

Main Methods:

  • Analyzed DTI data from 34 SLE patients and 29 controls.
  • Measured average diffusion constant (D(av)) and fractional anisotropy (FA).
  • Performed regional analysis in the corpus callosum, internal capsule, frontal lobe, and thalamus.

Related Experiment Videos

Main Results:

  • SLE patients showed significantly higher D(av) in the frontal lobe, splenium corpus callosum, and anterior internal capsule compared to controls.
  • Lower FA values were observed in the genu and splenium corpus callosum and anterior internal capsule in SLE patients.
  • These DTI changes were present even in SLE patients with normal routine MRI findings.

Conclusions:

  • Quantitative DTI reveals early, preclinical brain changes in SLE patients.
  • Increased D(av) and decreased FA may indicate early central nervous system involvement.
  • DTI can aid in early diagnosis, monitoring disease progression, and treatment efficacy in SLE.