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Functional plasticity in memory T helper cell responses.

Connie M Krawczyk1, Hao Shen, Edward J Pearce

  • 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|March 21, 2007
PubMed
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Immune memory T cells (Th1 and Th2) can switch cytokine production. Memory Th1 cells can produce IL-4, and memory Th2 cells can produce IFN-gamma when reactivated under specific conditions.

Area of Science:

  • Immunology
  • Cellular Biology
  • T cell differentiation

Background:

  • Naive CD4+ T helper (Th) cells differentiate into Th1 or Th2 lineages, typically losing the ability to produce cytokines of the alternative lineage.
  • This lineage commitment has been considered largely absolute in murine CD4+ T cells.

Purpose of the Study:

  • To investigate the plasticity of Th1 and Th2 memory cell cytokine production.
  • To determine if memory T cells can produce cytokines characteristic of the opposing lineage.

Main Methods:

  • Reactivation of Th1 and Th2 memory cell populations in vivo under conditions favoring the alternative lineage.
  • Assessment of cytokine production (IFN-gamma and IL-4) from reactivated memory cells.

Main Results:

Related Experiment Videos

  • Th2 memory cells produced IFN-gamma when reactivated in a Th1-promoting environment.
  • Th1 memory cells produced IL-4 when reactivated in a Th2-promoting environment.
  • Both effector and central memory cells retained the potential for alternative cytokine production.

Conclusions:

  • Murine Th1 and Th2 memory cells are not rigidly committed to their original lineage.
  • Memory T cells can respond to environmental cues to produce pathogen-appropriate cytokines of the opposing lineage.
  • This plasticity in memory T cells offers a broader immune response capability.