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Hereditary bleeding disorders in Riyadh, Saudi Arabia.
I M Al-Fawaz1, A M Gader, H M Bahakim
1Departments of Pediatrics, Physiology, Internal Medicine, College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia.
Annals of Saudi Medicine
|May 1, 1996
Summary
This study analyzed 168 patients with hereditary bleeding disorders (HBD) in Riyadh. Platelet disorders were more common than in Western countries, likely due to increased consanguinity.
Area of Science:
- Hematology
- Genetics
- Internal Medicine
Background:
- Hereditary bleeding disorders (HBD) represent a group of genetic conditions affecting hemostasis.
- Understanding the prevalence and distribution of HBD is crucial for diagnosis and management.
Purpose of the Study:
- To analyze the spectrum of hereditary bleeding disorders in a Saudi Arabian population.
- To compare the HBD profile with international data.
Main Methods:
- Retrospective analysis of 168 patients with suspected bleeding disorders over eight years.
- Categorization of patients based on diagnosed HBD, including coagulation factor deficiencies, Von Willebrand's disease, and qualitative platelet disorders.
Main Results:
- Coagulation factor deficiencies were most common (hemophilia A and B, factor deficiencies).
- Von Willebrand's disease affected 25 patients across 15 families.
- Qualitative platelet disorders were notably increased compared to Western populations, with Glanzmann's thrombasthenia and Bernard-Soulier disease identified.
Conclusions:
- The distribution of HBD in Riyadh shows similarities to Western countries but with a higher prevalence of platelet disorders.
- Increased consanguinity in the community may contribute to the higher incidence of platelet disorders.
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