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Related Experiment Videos

Monodisperse liquid-filled biodegradable microcapsules.

Cory Berkland1, Emily Pollauf, Neel Varde

  • 1Department of Chemical and Petroleum Engineering, 2030 Becker Dr., Lawrence, Kansas 66047, USA. berkland@ku.edu

Pharmaceutical Research
|March 21, 2007
PubMed
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Precision Particle Fabrication (PPF) technology enables scalable production of monodisperse liquid-filled microcapsules with controlled size and shell thickness. This method offers precise control over encapsulation for potential pharmaceutical and nutraceutical delivery applications.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Encapsulating liquids in biodegradable polymer microcapsules is challenging due to production issues like viscosity and phase stabilization.
  • Existing methods face limitations in scalability and precise control over microcapsule properties.

Purpose of the Study:

  • To extend Precision Particle Fabrication (PPF) technology for producing monodisperse liquid-filled microcapsules.
  • To compare PPF-produced microcapsules with double-walled microspheres.
  • To demonstrate control over core/shell properties and molecular localization.

Main Methods:

  • Utilized a coaxial nozzle within PPF technology to create a liquid core jet surrounded by a polymer jet.
  • Employed a non-solvent carrier stream and acoustic waves for droplet formation.

Related Experiment Videos

  • Hardened the shell via solvent extraction to create uniform, liquid-filled microcapsules.

    • Main Results:

    • Achieved monodisperse polymeric microcapsules with narrow size distribution and continuous shells.
    • Demonstrated efficient encapsulation of various oil and aqueous liquid cores.
    • Confirmed phase separation and molecular partitioning using fluorescent probes and showed pulsatile release of encapsulated proteins.

    Conclusions:

    • PPF technology offers exceptional control over microcapsule size and shell thickness for diverse liquid cores.
    • This technique shows promise for advanced delivery systems in pharmaceuticals and nutraceuticals.