Organ dysfunction and long term outcome in secondary peritonitis

Area of Science:

• Critical Care Medicine
• Surgical Infections
• Prognostic Biomarkers

Background:

• Secondary peritonitis presents significant mortality challenges, particularly with co-occurring multiorgan dysfunction.
• Current prognostic tools for long-term outcomes in these patients are insufficient, necessitating further research.

Purpose of the Study:

• To evaluate prognostic factors for patient outcomes in secondary peritonitis.
• To assess the predictive capability of organ dysfunction scores for mortality.

Main Methods:

• A cohort of 163 patients with secondary peritonitis (excluding trauma/postoperative) was analyzed.
• Organ dysfunction was quantified using the Sequential Organ Failure Assessment (SOFA) score in 58 ICU patients.
• Predictive factors for mortality and hospital/1-year survival rates were assessed.

Main Results:

• Hospital mortality was 19% and 1-year mortality was 23%.
• APACHE II, prior functional status, and sepsis category predicted fatal outcomes in the overall cohort.
• In ICU patients, advanced age and admission SOFA score independently predicted death, with SOFA demonstrating the highest discriminative ability (AuROC 0.78).

Conclusions:

• The degree of organ dysfunction, as measured by the SOFA score, is the most significant predictor of hospital mortality in secondary peritonitis.
• SOFA score serves as a valuable tool for risk stratification in patients with secondary peritonitis.