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Updated: Jul 16, 2026

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

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Published on: December 9, 2022

Progenitor cells and retinal angiogenesis.

Martin Friedlander1, Michael I Dorrell, Matthew R Ritter

  • 1Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92014, USA. friedlan@scripps.edu

Angiogenesis
|March 21, 2007
PubMed
Summary

Stem cells from bone marrow can repair damaged retinal vasculature and protect neurons in preclinical models. This approach offers a novel therapeutic strategy for degenerative eye diseases.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Stem cells (SC) offer potential for tissue repair in damaged retinas.
  • Current treatments for retinal diseases can be destructive.
  • Hypoxic damage and neovascularization are key pathological features in retinal diseases.

Purpose of the Study:

  • To investigate the potential of autologous bone marrow (BM)-derived hematopoietic stem cells (SC) for retinal repair.
  • To explore SC's ability to mature neovasculature and stabilize existing vasculature against hypoxic damage.
  • To assess SC's capacity to rescue retinal neurons from apoptosis.

Main Methods:

  • Isolation and characterization of endothelial and myeloid progenitor cells from adult BM.
  • Intravitreal injection of SC into mouse models of retinal degeneration.
  • Assessment of vascular rescue, neuronal survival, and functional outcomes.

Main Results:

  • Adult BM contains progenitor cells that target activated astrocytes and participate in angiogenesis.
  • Intravitreal SC injection prevented retinal vascular degeneration in mouse models.
  • Vascular rescue achieved through SC transplantation correlated with functional neuronal rescue.

Conclusions:

  • Autologous adult BM-derived SC grafts represent a novel therapeutic approach for retinal vascular and degenerative diseases.
  • SC transplantation can mature neovasculature, stabilize vasculature, and protect retinal neurons.
  • This SC-based therapy may obviate destructive treatments and promote vascularization in damaged retinal tissue.