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Updated: Jul 16, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Telomerase inhibition as an adjuvant anticancer therapy: it is more than just a waiting game
Abstract:
A telomere maintenance mechanism is essential for cancer cells to divide indefinitely. As telomerase maintains telomeres in the vast majority of human cancers, targeting tumor cells in patients with antitelomerase-based strategies is very appealing. However, as the complexities of telomere dynamics and telomerase regulation and function continue to unfold, translating this knowledge into well-designed clinical trials becomes daunting. Here, the authors discuss potential shortcomings for antitelomerase approaches and predict that inhibition of telomerase will be an effective targeted approach against cancer as a polytherapy in the adjuvant setting.
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