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Updated: Jul 16, 2026
06:39
A High Performance Impedance-based Platform for Evaporation Rate Detection
Published on: October 17, 2016
Tape-stripping method in man: comparison of evaporimetric methods
Hongbo Zhai1, Emi Dika, Marina Goldovsky
1Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143-0989, USA. zhaih@derm.ucsf.edu
Summary
Both open and closed chamber devices provide similar transepidermal water loss (TEWL) measurements on stripped human skin. This study confirms their comparable performance in a tape-stripping model, offering reliable data for skin barrier research.
Area of Science:
- Dermatology
- Biophysics
Background:
- Closed chamber evaporimeters risk saturation with prolonged occlusion.
- Previous comparisons of open and closed chamber devices were on intact skin.
- Data on stripped skin with higher evaporation rates are limited.
Purpose of the Study:
- To compare the sensitivity and correlation of open and closed chamber devices.
- To evaluate TEWL measurements in a human tape-stripping model.
- To quantify stratum corneum (SC) removed during tape stripping.
Main Methods:
- Ten healthy volunteers participated in a randomized, paired comparison study.
- Transepidermal water loss (TEWL) was measured using both open and closed chamber devices.
- Twenty tape strippings were performed on each forearm, with measurements taken after 10 and 20 strippings.
Main Results:
- Mean TEWL values were similar between the open and closed chamber devices after 10 and 20 tape strippings.
- No statistically significant differences were observed in TEWL measurements between the two devices.
- Stratum corneum (SC) aggregates in tape strips were comparable and showed no significant differences.
Conclusions:
- Both open and closed chamber evaporimeters are suitable for measuring TEWL on stripped human skin.
- The devices demonstrate comparable performance in a tape-stripping model.
- Findings support the use of either device for in vivo studies of skin barrier function.
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