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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Plasma serotonin levels are normal in pulmonary arterial hypertension
David J Lederer1, Evelyn M Horn, Erika B Rosenzweig
1Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Abstract:
Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with increased six-minute walk distance (r=0.55, p=0.04). These data suggest that plasma 5-HT levels are normal in PAH. Plasma 5-HT may therefore not be a useful biomarker in this condition.
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