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Related Experiment Videos

Hormonal responses to trauma.

P D Woolf1

  • 1Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642.

Critical Care Medicine
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Trauma causes bidirectional hormonal shifts, with some hormones increasing and others decreasing. These endocrine changes reflect injury severity and may predict outcomes, but their full clinical relevance requires further study.

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Area of Science:

  • Endocrinology
  • Trauma Medicine
  • Physiology

Background:

  • Trauma significantly impacts the endocrine system.
  • Understanding hormonal responses is crucial for patient management.

Purpose of the Study:

  • Review hormonal changes post-trauma.
  • Define etiologies of these endocrine derangements.
  • Describe the consequences of hormonal alterations.

Main Methods:

  • Comprehensive literature review utilizing MEDLINE database.
  • Inclusion of original research data for analysis.

Main Results:

  • Bidirectional hormonal responses observed: increases in ACTH, cortisol, GH, prolactin; decreases in gonadotropins, gonadal steroids, thyroid hormones.

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  • Timing of hormonal changes varies: immediate for some increases, delayed and persistent for decreases.
  • Thyroid hormone reduction involves altered metabolism and clearance, not just secretion.

    • Conclusions:

    • Hormonal changes correlate with trauma severity, not specific injury types.
    • Cortisol and thyroxine levels may have predictive value.
    • Head injuries can cause pituitary structural/functional changes, leading to insufficiency; hyperprolactinemia suggests hypothalamic involvement.