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Functional linkage between NOXA and Bim in mitochondrial apoptotic events

Jie Han1, Leslie A Goldstein, Wen Hou

  • 1Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA.

The Journal of Biological Chemistry
|March 22, 2007
PubMed
Summary

NOXA protein binding to Mcl-1 displaces Bim, enhancing UV-induced cell death. This NOXA-Bim interaction, mediated by Mcl-1, is crucial for mitochondrial depolarization during apoptosis.

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