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Updated: Jul 16, 2026
06:28
Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures (MAAC)
Published on: February 13, 2020
Innate immunity modulates adipokines in humans
Paul D Anderson1, Nehal N Mehta, Megan L Wolfe
1Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104-6160, USA.
The Journal of Clinical Endocrinology and Metabolism
|March 22, 2007
Summary
Low-grade endotoxemia significantly altered adipokine signaling, increasing leptin and resistin while suppressing adiponectin receptors. This suggests a link between inflammation, insulin resistance, and atherosclerosis.
Area of Science:
- Endocrinology
- Immunology
- Metabolic Research
Background:
- Chronic inflammation is a key factor in type 2 diabetes and atherosclerosis.
- Adipokines play a crucial role in insulin resistance and cardiovascular disease.
- Modulating adipokine signaling via innate immunity is of significant interest.
Purpose of the Study:
- To investigate the effects of low-grade endotoxemia on adipokines in vivo.
- To utilize a model of human inflammation to study adipokine responses.
Main Methods:
- A clinical study involving 20 healthy volunteers (male and female).
- Administration of lipopolysaccharide (LPS) to induce endotoxemia.
- Serial blood sampling and adipose tissue biopsies for analysis of adipokines, receptors, and inflammatory markers.
Main Results:
- LPS induced fever, increased TNF and IL-6, and elevated insulin resistance markers.
- Plasma leptin and resistin levels significantly increased, as did the leptin:soluble leptin receptor ratio.
- Adiponectin levels remained unchanged, but mRNA for adiponectin receptors 1 and 2 was suppressed.
Conclusions:
- Adipokine signaling modulation may contribute to the insulin-resistant and atherogenic state seen in inflammatory conditions.
- Targeting specific adipokines or their regulatory pathways could help prevent inflammation-related metabolic complications.
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