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Optimisation of anti-psychotic therapeutics: a balancing act?
1Howard Florey Institute and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, Australia. Andrew.Lawrence@hfi.unimelb.edu.au
Abstract:
Schizophrenia is a complex and debilitating disorder. Although effective therapeutic strategies are available, these are not without problems and are not universally efficacious. In this issue of the British Journal of Pharmacology, a trio of papers describe the characterisation of a potential, novel anti-psychotic medication, F15063. This compound combines antagonism of dopamine D(2)-like receptors with agonism at 5-HT(1A) receptors. Based on in vitro and in vivo profiles, the authors suggest that this compound approaches the 'optimal balance' for activity at these receptor systems.
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