Related Experiment Video
Updated: Jul 16, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation
Chozhavendan Rathinam1, Christoph Klein
1Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
Abstract:
Hematopoietic stem cell differentiation is specified by cytokines and transcription factors, but the mechanisms controlling instructive and permissive signalling networks are poorly understood. We provide evidence that CLP1-dependent IL7-receptor mediated B cell differentiation is critically controlled by the transcriptional repressor Gfi1. Gfi1-deficient progenitor B cells show global defects in IL7Ralpha-dependent signal cascades. Consequently, IL7-dependent trophic, proliferative and differentiation-inducing responses of progenitor B cells are perturbed. Gfi1 directly regulates expression levels of IL7Ralpha and indirectly controls STAT5 signalling via expression of SOCS3. Thus, Gfi1 selectively specifies IL7-dependent development of B cells from CLP1 progenitors, providing clues to the transcriptional networks integrating cytokine signals and lymphoid differentiation.
Related Concept Videos
Master Transcription Regulators
Master Transcription Regulators
TGF - β Signaling Pathway
General Transcription Factors
Co-activators and Co-repressors
Co-activators and Co-repressors
