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Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during
Pattana Sornmayura1, Paisan Boonsakan, Abhasnee Sobhonslidsuk
1Department of Pathology, Ramathibodi Hospital, Bangkok, Thailand.
Objective:
Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions.
Material And Method:
Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.
Results:
One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.
Conclusion:
The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B, and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
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