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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jul 16, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

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Published on: December 15, 2011

Celiac disease: more common than you think.

Melanie S Harrison1, Mohammad Wehbi, Kamil Obideen

  • 1Emory University School of Medicine, Atlanta, GA, USA.

Cleveland Clinic Journal of Medicine
|March 23, 2007
PubMed
Summary

Celiac disease awareness is crucial, as many cases present atypically. Early diagnosis by primary physicians and support from dieticians improve patient outcomes with a necessary gluten-free diet.

Area of Science:

  • Gastroenterology
  • Immunology
  • Primary Care Medicine

Background:

  • Celiac disease is an immune-mediated gastrointestinal disorder.
  • Increasing recognition, but diagnosis is often delayed due to atypical or silent presentations.
  • High awareness is needed, particularly in primary care settings.

Purpose of the Study:

  • To emphasize the importance of high awareness for celiac disease diagnosis.
  • To highlight the role of primary care physicians in early detection.
  • To underscore the necessity and challenges of a gluten-free diet.

Main Methods:

  • Diagnosis relies on clinical suspicion.
  • Laboratory testing is essential for confirmation.
  • Primary care physician involvement is key.

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Main Results:

  • Half of celiac disease cases present atypically or silently.
  • Early diagnosis is associated with improved patient outcomes.
  • Dietitian and support group involvement enhances adherence to a gluten-free diet.

Conclusions:

  • Increased awareness of celiac disease is vital for timely diagnosis.
  • Primary care physicians play a critical role in identifying celiac disease.
  • Multidisciplinary support is essential for managing celiac disease through a gluten-free diet.