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Updated: Jun 11, 2026
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
Quantitative estimations of the entorhinal cortex in Alzheimer's disease
Emilio Artacho-Pérula1, Ricardo Insausti
1Human Neuroanatomy Laboratory, Department of Health Sciences, School of Medicine and Regional Center for Biomedical Investigation, University of Castilla-La Mancha, Albacete, Spain. emilio.artacho@uclm.es
Objective:
To detect and quantify structural parameters in the entorhinal cortex (EC) of potential use in Alzheimer's disease (AD).
Study Design:
We estimated by stereologic tools the total volume of the EC and subfields EI and ER, the number of neurons and the volume-weighted mean soma volume of layer II neurons. EC morphometric parameters were also assessed in both control and AD cases.
Results:
In AD, EC volume decreased by 35%, while total number of neurons reached 51%. Also, neuron density had a significant decrease mainly due to change in the EI subfield (31% decrease). The EC showed a decrease in size and a morphology more elliptic and irregular. Moreover, layer II neurons soma size (volume, area, and 1-dimensional parameters) were more rounded. Thus the EC decreases in size and neuron number in AD and minor changes in number per volume were noted.
Conclusion:
These quantitative data can be of value in volumetric MRI studies in AD patients.
