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Assembly and Characterization of Polyelectrolyte Complex Micelles
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Interactions between poloxamers in aqueous solutions: micellization and gelation studied by differential scanning

Franck Artzner1, Sandrine Geiger, Audrey Olivier

  • 1UMR CNRS 8612, Univ Paris-Sud, Faculté de Pharmacie, 5 rue JB Clément, 92296 Châtenay-Malabry Cedex, France.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 23, 2007
PubMed

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...