Related Experiment Video
Updated: Jul 16, 2026

16:38
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry
Richard A Decréau1, James P Collman, Ying Yang
1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
The Journal of Organic Chemistry
|March 23, 2007
Abstract:
Five alkyne-containing hemoprotein models have been synthesized in a convergent manner. Sonogashira coupling was used to introduce the alkyne functional group on the proximal imidazole before or after being attached on the porphyrin. One model was immobilized onto a gold electrode surface via copper(I)-catalyzed azide-alkyne cycloaddition (Sharpless click chemistry).

