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Lepromatous leprosy of histoid type
S R Annigeri1, S C Metgud, J R Patil
1Department of Microbiology, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India. sumatihogade@yahoo.co.in
Indian Journal of Medical Microbiology
|March 23, 2007
Summary
Histoid leprosy, a dapsone-resistant form of lepromatous leprosy, presents unique challenges. This report details two histoid leprosy cases, one typical and one atypical, highlighting diagnostic considerations.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Leprosy is a chronic infectious disease caused by Mycobacterium leprae.
- Dapsone monotherapy resistance can lead to lepromatous leprosy variants.
- Histoid leprosy is a rare manifestation of lepromatous leprosy.
Observation:
- Two cases of histoid leprosy were identified.
- One case presented with typical histoid features.
- The second case exhibited atypical clinical manifestations.
Findings:
- Histoid leprosy represents a distinct clinical and histological subtype.
- Resistance to dapsone monotherapy is a key factor in its development.
- Varied presentations necessitate careful diagnostic evaluation.
Implications:
- Understanding histoid leprosy is crucial for effective treatment strategies.
- Recognition of atypical forms aids in timely diagnosis and management.
- Further research into dapsone resistance mechanisms is warranted.
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