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Leukodepletion improves renal function in patients with renal dysfunction undergoing on-pump coronary bypass surgery:

C Bolcal1, H T Akay, H Bingol

  • 1Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.

The Thoracic and Cardiovascular Surgeon
|March 23, 2007
PubMed

Insights

Leukodepletion may protect kidney function in patients undergoing on-pump coronary artery bypass grafting (CABG) surgery. This method reduced markers of renal injury and the need for dialysis in patients with existing renal dysfunction.

Area of Science:

  • Cardiology
  • Nephrology
  • Transfusion Medicine

Background:

  • On-pump coronary artery bypass grafting (CABG) can impact renal function.
  • Leukodepletion is a technique used during blood transfusions.

Purpose of the Study:

  • To evaluate the effect of leukodepletion on renal function in patients undergoing on-pump CABG.
  • To assess if leukodepletion can prevent renal impairment and tubular damage.

Main Methods:

  • Fifty patients with normal preoperative cardiac function and mild renal dysfunction were randomized into two groups.
  • Group A (n=25) underwent on-pump CABG with leukodepletion; Group B (n=25) underwent on-pump CABG without leukodepletion.
  • Renal injury was assessed using plasma creatinine, blood urea nitrogen (BUN), and urinary alpha glutathione S-transferase (GST).

Main Results:

  • The leukodepletion group showed decreased levels of creatinine, BUN, and urinary GST post-surgery compared to the control group.
  • No mortality was observed in either group.
  • Three patients in the control group required postoperative dialysis, while none in the leukodepletion group did.

Conclusions:

  • Leukodepletion appears beneficial in preventing renal impairment and tubular damage in patients with renal dysfunction undergoing on-pump CABG.
  • The findings suggest leukodepletion is a valuable strategy to preserve kidney function in this patient population.
Abstract

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