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Updated: Jul 16, 2026
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
[Vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor-D (VEGF-D) in ovarian
Barbara Rossochacka-Rostalska1, Iwona Gisterek, Elzbieta Suder
1Katedra Onkologii i Klinika Onkologii Ginekologicznej Akademii Medycznej we Wrocławiu.
Objectives:
The aim of the work was to assess vascular endothelial growth factor VEGF-C and vascular endothelial growth factor VEGF-D expression in ovarian carcinomas.
Material And Methods:
Clinical records and preserved specimens from 80 patients with ovarian cacinoma who underwent treatment at Lower Silesia Centre of Oncology were examined consecutively.
Results:
Most of analysed patients (n=53) had serous adenocarcinomas at III or IV FIGO stage. The median VEGF-C expression analysed semiquantitively using immunohistochemistry method was 3.84, and in 5% of cases expression of marker was not found. Also median VEGF-D expression was 3.71, and reactivity of this cytokine was not found in 16.25% of cases. There was strong correlation between expression of VEGF-C and VEGF-D. Conversely, there was no significant correlation between VEGF-C and VEGF-D expression and clinicopathological features of ovarian carcinoma. Univariate analysis demonstrated that high expression of cytokines wasn't associated with worse survival rate.
Conclusion:
This incresistence indicated that studies on angiogenesis in ovarian carcinomas should be continued.
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