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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Jul 16, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
09:01

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

[Post-transplantation diabetes mellitus].

Karine Moreau1

  • 1Département de néphrologie, unité de néphrologie et transplantation rénale Professeur-Merville, hôpital Pellegrin-Tripode, place Amélie-Raba-Léon, 33076 Bordeaux, France. karine.moreau@chu-bordeaux.fr

Nephrologie & Therapeutique
|March 24, 2007
PubMed
Summary

Post-transplant diabetes mellitus (PTDM) is a common complication after organ transplants. Managing PTDM involves pre-transplant risk assessment and post-transplant monitoring and treatment to improve patient and graft survival.

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Context:

  • Post-transplant diabetes mellitus (PTDM) is a frequent and serious complication following organ transplantation.
  • Its development involves a complex interplay of intrinsic patient factors and graft-related elements, including immunosuppressive therapy.
  • In kidney transplant recipients, PTDM negatively impacts patient survival and increases infectious and cardiovascular complications.

Purpose:

  • To explore the ethiopathogenesis of PTDM.
  • To highlight the adverse effects of PTDM on patient and allograft survival.
  • To outline management strategies for PTDM.

Summary:

  • PTDM pathogenesis involves intrinsic factors (age, BMI, family history, HCV) and graft factors (immunosuppression, HLA status).

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Last Updated: Jul 16, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
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Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING)
07:36

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Published on: March 14, 2019

  • New onset diabetes mellitus post-transplant is linked to poorer patient survival and increased complications.
  • Management includes pre-transplant risk screening, regular post-transplant glycemic monitoring, and addressing cardiovascular risk factors.

    • Impact:

    • PTDM significantly affects long-term allograft survival.
    • Effective management strategies can mitigate the adverse outcomes associated with PTDM.
    • Early identification and intervention are crucial for improving outcomes in transplant recipients.