Related Experiment Video
Updated: Jul 16, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Crisis states in systemic lupus erythematosus]
Emese Kiss1, Tünde Tarr, Pál Soltész
1kiss@iiibel.dote.hu
Orvosi Hetilap
|March 24, 2007
Summary
Systemic lupus erythematosus (SLE) can lead to critical organ complications requiring intensive care. Prompt recognition and multidisciplinary management are vital for addressing severe lupus flares and improving patient outcomes.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Context:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease impacting multiple organs.
- Improved diagnostics and therapeutics have increased SLE patient survival.
- Despite advances, SLE patients remain susceptible to critical, life-threatening complications.
Purpose:
- To summarize critical complications of SLE.
- To highlight situations necessitating urgent therapeutic changes and hospitalization, including intensive care.
Summary:
- SLE can affect all major organs, leading to heart failure, respiratory and renal insufficiency, and severe central nervous system issues.
- Complications arise from acute flares or chronic progression, triggered by infections, pregnancy, therapy withdrawal, or stress.
- Critical situations may stem directly from SLE, its treatments, or co-existing conditions.
Impact:
- Effective management of SLE requires recognizing and addressing critical complications.
- Multidisciplinary collaboration is essential for managing severe lupus crises.
- Specialized immunologic centers are crucial for organizing and delivering optimal care for complex SLE cases.
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