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Alpha-synuclein multistate folding thermodynamics: implications for protein misfolding and aggregation

Allan Chris M Ferreon1, Ashok A Deniz

  • 1Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines MB-19, La Jolla, California 92037, USA.

Biochemistry
|March 24, 2007
PubMed
Summary

Alpha-synuclein folding is multistate, involving two helical intermediates. This intrinsic propensity for multiple structures may impact its role in Parkinson's disease pathogenesis and toxicity.

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