Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD5-positive B-cell acute lymphoblastic leukemia.

Michael R Peterson1, Kyle J Noskoviak, Robert Newbury

  • 1Department of Pathology, University of California, San Diego, and Children's Hospital and Health Center of San Diego, CA 92123, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|March 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases.

Neuro-oncology·2026
Same author

Rare presentation of juvenile xanthogranuloma in the posterior fossa of a toddler.

BMJ case reports·2021
Same author

Congenital cutaneous non-neural granular cell tumor mimicking herpetic infection: Case report and review of the literature.

Pediatric dermatology·2021
Same author

Non-invasive intradermal imaging of cystine crystals in cystinosis.

PloS one·2021
Same author

Rare case of extranodal Rosai-Dorfman disease presenting as a middle cranial fossa tumour.

BMJ case reports·2021
Same author

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2020

CD5-positive B-cell acute lymphoblastic leukemia (ALL) is a rare and aggressive cancer in adolescents. This rare ALL subtype presents with poor outcomes and can be misdiagnosed as other small blue-cell tumors.

Area of Science:

  • Hematology
  • Oncology
  • Pediatric Oncology

Background:

  • CD5-positive B-cell acute lymphoblastic leukemia (ALL) is an exceptionally rare hematologic malignancy.
  • Limited literature exists, with only one prior case report.

Observation:

  • Two new cases of CD5-positive B-cell ALL in adolescent patients (16-year-old male, 15-year-old female) are presented.
  • The first case was initially misdiagnosed as Ewing sarcoma due to atypical CD45 and CD99 expression.
  • The second case exhibited trisomy 22, a novel cytogenetic finding in ALL.

Findings:

  • CD5-positive B-cell ALL is associated with aggressive disease progression.
  • Both reported patients experienced poor clinical outcomes.
  • The previously reported case also had a poor prognosis.

Related Experiment Videos

Implications:

  • CD5-positive B-cell ALL represents a rare but aggressive malignancy with a poor prognosis, primarily affecting adolescents.
  • Awareness among pathologists and clinicians is crucial to prevent misdiagnosis, particularly differentiating it from other small blue-cell tumors.
  • This entity requires specific diagnostic considerations due to its rarity and aggressive nature.