Related Experiment Video
Updated: Jul 16, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
The influence of the immunostimulation by bacterial cell components derived from altered large intestinal microbiota
Mitsuharu Matsumoto1, Kurt Hara, Yoshimi Benno
1Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd, Hirai, Hinode, Tokyo, Japan. m-matumoto@meito.co.jp
Abstract:
Using murine macrophage-like J774.1 cells and fecal precipitates prepared from the feces of elderly volunteers whose acute inflammation had been inhibited by LKM512 yogurt consumption, we investigated the likelihood that immunostimulation by altered intestinal bacterial cell components contribute to the anti-inflammatory benefits of this yogurt. Tumor necrosis factor-alpha production due to stimulation by fecal precipitates obtained during LKM512 yogurt consumption tended to be higher than due to stimulation by precipitates obtained from preconsumption (P=0.0827), although acute phase response was suppressed by LKM512 yogurt consumption. We suggest that the anti-inflammatory benefits of LKM512 yogurt on elderly volunteers are independent of direct immunostimulation by the bacterial cell components derived from altered intestinal microbiota.
Related Concept Videos
Microbiota Modulation by Antibiotics
Probiotics
Dysbiosis of the Gut Microbiota
Functions of the Gut Microbiota
Microorganisms in Medicine and Therapeutics
Development of Human Microbiota
