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Using the single-compartment ratio model to calculate half-life, NT-proBNP as an example

Martin H Kroll1, Patrick J Twomey, Pornpen Srisawasdi

  • 1Dallas VA Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75216, USA. martin.kroll@med.va.gov

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 24, 2007
PubMed
Summary

The half-life of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in humans is approximately 25 minutes, significantly shorter than previously reported. This finding, using a single-compartment model, suggests NT-proBNP is useful for short-term patient monitoring.

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