Schwann cell graft: a method to promote sensory responses of osseointegrated implants

Osseointegrated dental implants have been widely used in clinics to restore the missing teeth of patients. Since there are no periodontal ligament and associated Ruffini endings in the peri-implant tissues, sensory thresholds of the implant are much higher than those of natural teeth, and its self-protective reflex is quit poor. Implant fracture or aggressive bone loss sometimes occurs because the patient cannot feel the overloads exerted on the implant. Until now, no available method has been issued to solve such a problem. Schwann cell is the glial cell of peripheral nerve system. It has been widely accepted to play indispensable roles during neural development and regeneration. Its mechanism includes forming Büngner's band, producing neurotrophic factors, synthesizing surface cell adhesion molecules, and elaborating basement membrane. Furthermore, Schwann cell is quite important for the periodontal Ruffini endings. Applying these functions of Schwann cells, we put forward a hypothesis that transplanting Schwann cells into the implant site can be a method to promote sensory responses of the dental implants.