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Updated: Jul 16, 2026

Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

Clonal interference is alleviated by high mutation rates in large populations

Jonathan P Bollback1, John P Huelsenbeck

  • 1Institute of Biology, University of Copenhagen, Copenhagen, Denmark. bollback@binf.ku.dk

Molecular Biology and Evolution
|March 24, 2007
PubMed
Summary

In asexual populations, clonal interference slows evolution. However, very high mutation rates (Nmu) can overcome this by rapidly creating beneficial mutations, reducing the need for recombination and ameliorating the cost of asexuality.

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