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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Angiographic and clinical outcome following sirolimus-eluting stent (Cypher) implantation. A single center experience
Turkay Ozcan1, V Gokhan Cin, Mustafa Yurtdas
1Department of Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Insights
Sirolimus-eluting stents (Cypher) show high success rates and positive long-term outcomes in coronary artery disease patients. These drug-eluting stents effectively reduce restenosis, improving patient event-free survival.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Drug-eluting stents (DES) are designed to minimize intimal hyperplasia, a primary factor in in-stent restenosis.
- Sirolimus-eluting stents have demonstrated significant reductions in both clinical and angiographic restenosis rates.
- These stents are associated with improved event-free survival in patients with coronary artery disease.
Purpose of the Study:
- To evaluate the long-term clinical and angiographic outcomes of sirolimus-eluting stent (Cypher) implantation.
- To assess the safety and efficacy of Cypher stents in patients with significant coronary artery disease.
Main Methods:
- A cohort of 207 patients (273 Cypher stents) with symptomatic coronary artery disease and significant stenosis (>70%) were enrolled.
- Follow-up coronary angiography was conducted at 18 months post-implantation.
- Patients were monitored for a mean duration of 24.7 months for clinical events.
Main Results:
- All patients survived the initial stent implantation procedure.
- Acute ST-elevation myocardial infarction occurred in 2.4% of patients, and non-Q wave myocardial infarction in 1.9%.
- Restenosis was observed in 9.66% of patients, leading to revascularization in 5.3% (angioplasty) and 4.3% (coronary artery bypass grafting).
Conclusions:
- Sirolimus-eluting (Cypher) stents can be implanted with a very high success rate.
- The study demonstrates encouraging long-term angiographic and clinical results for Cypher stent use.
- These findings support the efficacy of sirolimus-eluting stents in managing coronary artery disease.
Objectives:
To investigate the late outcomes of sirolimus-eluting stent implantation in patients with coronary artery disease.
Background:
Drug-eluting stents reduce intimal hyperplasia, which is the main cause of in-stent restenosis. Sirolimus-eluting stents significantly reduce clinical and angiographic restenosis and improve event-free survival.
Methods:
The study population consisted of 207 patients (273 stents) who had undergone coronary Cypher stent implantation. Patients were eligible for enrollment if there was symptomatic coronary artery disease or positive exercise testing, and angiographic evidence of single or multivessel disease with a target lesion stenosis of > or = 70% in a > or = 2.25 mm vessel. Follow-up coronary angiography was performed 18 months after stent deployment. Patients were followed-up for a mean of 24.7 +/- 7.4 months.
Results:
All patients survived after stent implantation, but 5 (2.4%) patients experienced acute ST elevation myocardial infarction and 4 (1.9%) patients developed non-Q wave myocardial infarction following angioplasty. Recurrent angina pectoris was observed in 16 (7.7%) patients (11 stable angina pectoris and 5 unstable angina pectoris). Angiographic evidence of restenosis was observed in these 20 (9.66%) patients. The 5 other patients had noncritical angiographic restenosis. Eleven (5.3%) patients underwent angioplasty because of restenosis, and coronary artery bypass grafting was conducted in the other 9 (4.3%) patients.
Conclusion:
The results of the present study indicate that Cypher stents could be implanted with a very high success rate and have encouraging long-term angiographic and clinical results.
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