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Oligodendrogliomas: the Mayo Clinic experience
E G Shaw1, B W Scheithauer, J R O'Fallon
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Journal of Neurosurgery
|March 1, 1992
Summary
Tumor grade and extent of surgical resection significantly impact survival in oligodendroglioma patients. Postoperative radiation therapy did not show a clear survival benefit in this historical cohort.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Pure supratentorial oligodendrogliomas are a distinct group of brain tumors.
- Treatment strategies have evolved, necessitating evaluation of historical data.
Purpose of the Study:
- To analyze prognostic factors affecting survival in oligodendroglioma patients.
- To evaluate the impact of surgical resection extent and radiation therapy on survival.
Main Methods:
- Retrospective analysis of 81 patients treated between 1960-1982.
- Univariate and multivariate survival analyses were performed.
- Prognostic factors included tumor grade, surgical resection, and radiation therapy details.
Main Results:
- Tumor grade (Kernohan and St. Anne-Mayo) was the strongest prognostic factor.
- Gross total resection significantly improved median survival (12.6 years) compared to subtotal resection (4.9 years).
- High-dose postoperative radiation therapy (≥5000 cGy) showed a survival benefit in patients with subtotal resection.
Conclusions:
- Tumor grade and extent of surgical resection are critical determinants of survival in oligodendroglioma.
- Postoperative radiation therapy may benefit patients with subtotal resection, particularly at higher doses.
- Further research is needed to clarify the role of radiation in modern treatment paradigms.