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Updated: Jul 16, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

[Von Willebrand factor activity in patients with systemic lupus erythematosus]

S V Shevchuk

    Likars'Ka Sprava
    |March 27, 2007
    PubMed

    Eighty four SLE patients have been studied. The levels of Willebrand factor, total antibodies to cardiolipin class IgG, antibodies to D-DNA, total index of inflammatory process activity SLEDAI and other routine markers have been assessed. Endothelial-dependent vasodilatation of brachial artery and carotid intima-media thickness was found to exceed that of control group twice as much. The elevation of Willebrand factor is associated with increase in SLE activity and correlated with SLEDAI index, C-reactive protein level and total antibody content to IgG class phospholipids. The elevation of Willebrand factor activity is also associated with endothelial-dependent vasodilatation impairment in patients with high inflammatory process activity in particular.

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