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Calcitonin levels do not decrease with weaning in chronic alcoholism.

M C Vantyghem1, T Danel, S Marcelli-Tourvieille

  • 1Endocrinology and Metabolism Department, Lille University Hospital, Lille Cedex, France. mc-vantyghem@chru-lille.fr

Thyroid : Official Journal of the American Thyroid Association
|March 27, 2007
PubMed
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Chronic alcohol consumption in men is linked to higher calcitonin (CT) levels compared to non-drinkers. Alcohol weaning did not significantly alter CT levels in this study. These findings are crucial for interpreting borderline CT values in thyroid nodule assessment.

Area of Science:

  • Endocrinology
  • Toxicology
  • Internal Medicine

Background:

  • Alcohol consumption is suspected to elevate calcitonin (CT) levels.
  • Existing data primarily stems from acute alcohol exposure studies in animals and humans.
  • The impact of chronic alcohol intoxication on plasma CT requires further investigation.

Purpose of the Study:

  • To investigate the effect of chronic alcoholic intoxication on plasma calcitonin (CT) levels in male subjects.
  • To compare CT levels in chronically alcoholic individuals with a control group.
  • To assess changes in CT levels during a short period of alcohol withdrawal.

Main Methods:

  • 20 male subjects with chronic daily alcohol consumption (>100 g) were enrolled.
  • Blood samples were collected at admission (T0), and after 5 (T5) and 21 (T21) days of alcohol weaning.

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  • Plasma CT, gamma-glutamyltransferase (GGT), and other biochemical parameters were measured; a control group (alcohol consumption <20 g/day) was included.

    • Main Results:

    • Mean CT levels in the alcohol group (6.4-8.4 pg/mL) were significantly higher than in the control group (3.1 pg/mL) (p <0.0001).
    • No significant decrease in CT levels was observed during the 21-day alcohol weaning period.
    • Gamma-glutamyltransferase (GGT) levels significantly decreased with longer weaning duration (p <0.05).

    Conclusions:

    • Chronically alcoholic smoking males exhibit elevated plasma CT levels compared to age- and sex-matched controls.
    • Most alcoholic patients had CT levels below the 10 pg/mL threshold.
    • These findings are relevant for interpreting borderline CT values in clinical settings, particularly for thyroid nodule assessment.