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Published on: July 14, 2023
N-terminal-pro-B-type natriuretic peptide in acute hyperthyroidism
Marianne Schultz1, Caroline Kistorp, Bente Langdahl
1Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark. Marianne.Schultz@frh.regionh.dk
Summary
Thyroid hormones directly influence NT-proBNP levels in healthy women. Acute hyperthyroidism increased NT-proBNP, suggesting T3 hormone action on secretion, not cardiac workload.
Area of Science:
- Endocrinology
- Cardiovascular Biomarkers
Background:
- Serum N-terminal-pro-B-type natriuretic peptide (NT-proBNP) is elevated in heart failure.
- Thyroid hormones may directly stimulate NT-proBNP synthesis.
Purpose of the Study:
- To investigate the effect of acutely induced hyperthyroidism on serum NT-proBNP levels.
Main Methods:
- Forty-three healthy women received triiodothyronine (T3) for 7 days.
- Serum NT-proBNP, free T3, and TSH levels were measured before and after treatment.
Main Results:
- T3 therapy increased free T3 and decreased TSH.
- Median NT-proBNP increased significantly (p < 0.0001).
- Increased NT-proBNP was associated with higher free T3 and lower TSH, independent of cardiac workload changes.
Conclusions:
- Thyroid function influences NT-proBNP in healthy women.
- Acute hyperthyroidism increases NT-proBNP, likely via direct T3 action on secretion.
- This suggests NT-proBNP reflects thyroid status beyond cardiac workload.
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