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Updated: Jul 16, 2026

Experimental Metastasis Assay
Published on: August 24, 2010
Genetic polymorphisms and metastatic breast cancer survival
1Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA. kristina.allen@utah.edu
Abstract:
Variability of disease progression and survival exists among metastatic breast cancer patients. Treatment efficacy may be dependent on genetic variants in DNA repair and cell-cycle regulatory genes. This study examined three genetic variants in DNA repair and cell-cycle control genes (XRCC1, XRCC3 and CCND1) in 95 patients treated with high-dose chemotherapy. They found that all three were significantly associated with disease progression and survival independently, and that combinations of these variants progressively worsened breast cancer survival. Prior to identifying these genetic variants as prognostic indicators, replication of results in large randomized trials using standard treatment regimens is warranted.
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