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Inappropriate prescribing in the elderly.

P Gallagher1, P Barry, D O'Mahony

  • 1Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland.

Journal of Clinical Pharmacy and Therapeutics
|March 27, 2007
PubMed
Summary
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Potentially inappropriate prescribing in older adults is common, affecting up to 40% of nursing home residents and linked to adverse drug events. More research is needed to confirm the benefits of drug review tools.

Area of Science:

  • Geriatric Pharmacology
  • Medication Safety
  • Health Services Research

Background:

  • Optimizing drug therapy in older patients is complex, with potential for harm.
  • Drug utilization review (DUR) tools can identify potentially inappropriate prescribing (PIP) in elderly pharmacotherapy.
  • PIP poses risks to elderly patients, necessitating effective detection and intervention strategies.

Purpose of the Study:

  • To review the existing literature on potentially inappropriate prescribing in the elderly.
  • To examine explicit criteria developed for detecting PIP in older populations.

Main Methods:

  • Conducted a literature search of the PUBMED database (1991-2006).
  • Performed manual searches of major journals for referenced articles.

Related Experiment Videos

  • Utilized search terms including 'elderly', 'inappropriate prescribing', 'prevalence', 'Beers criteria', 'health outcomes', and 'Europe'.

    • Main Results:

    • PIP is highly prevalent in the US and Europe, ranging from 12% in community-dwelling elderly to 40% in nursing home residents.
    • PIP is associated with adverse drug events.
    • Limited data exists on health outcomes related to PIP, and no prospective studies validate the clinical benefits of DUR tools.

    Conclusions:

    • Prospective randomized controlled trials are essential to identify effective interventions for reducing PIP.
    • DUR tools should be evidence-based and tailored to national drug formularies and prescribing practices.
    • Addressing PIP requires further research and development of context-specific interventions.