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Updated: Jul 16, 2026
13:45
Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Complete spontaneous regression in Merkel cell carcinoma
Martin J J Vesely1, Dylan J Murray, Peter C Neligan
1Division of Plastic Surgery, University of Toronto, University Health Network, Wharton Head & Neck Centre, Toronto, Ontario, Canada.
Summary
Merkel cell carcinoma, a rare skin cancer, can spontaneously regress. This case study details a patient whose cheek Merkel cell carcinoma completely disappeared after biopsy, with no residual tumor found later.
Area of Science:
- Dermatology
- Oncology
Background:
- Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer primarily affecting the elderly.
- MCC incidence is increasing globally, posing a significant public health challenge.
- The prognosis for MCC is generally poor, highlighting the need for effective treatment strategies.
Observation:
- A case report of a 67-year-old female patient with Merkel cell carcinoma on her cheek is presented.
- Following a diagnostic biopsy, the Merkel cell carcinoma lesion exhibited complete spontaneous regression.
- Surgical excision performed seven weeks post-biopsy revealed no evidence of residual tumor.
Findings:
- The presented case adds to the limited literature on spontaneous regression in Merkel cell carcinoma.
- Complete regression following biopsy suggests a potential immune-mediated response or other unknown factors.
- This observation challenges the typically aggressive nature and poor prognosis associated with MCC.
Implications:
- Understanding spontaneous regression mechanisms in MCC could lead to novel therapeutic approaches.
- Further research into immune responses in Merkel cell carcinoma is warranted.
- This case underscores the importance of continued monitoring and reporting of rare oncological phenomena.
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