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Related Experiment Video

Updated: Jul 7, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

The tail end of membrane insertion.

Elisabet C Mandon¹, Reid Gilmore

¹Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

|March 27, 2007

Summary

Researchers identified a soluble receptor that uses ATP to insert tail-anchored membrane proteins into cellular membranes. This discovery sheds light on the poorly understood mechanism of tail-anchored protein insertion.

Area of Science:

Molecular Biology
Cell Biology
Protein Biochemistry

Background:

Tail-anchored membrane proteins are crucial for cellular functions.
Their insertion into cellular membranes occurs post-translationally via a C-terminal tail-anchor.
The precise mechanism governing this insertion process remains largely elusive.

Discussion:

This study identifies a novel soluble receptor essential for tail-anchored membrane protein insertion.
The receptor utilizes ATP, indicating an energy-dependent pathway.
This finding provides a mechanistic link between protein synthesis and membrane targeting.

Key Insights:

Identification of a soluble, ATP-dependent receptor for tail-anchored membrane protein insertion.
Characterization of a key player in the post-translational membrane protein targeting pathway.

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Last Updated: Jul 7, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

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Elucidation of a novel mechanism for integrating proteins into cellular membranes.

Outlook:

Further investigation into the receptor's structure and function.
Exploring the broader implications for protein biogenesis and cellular homeostasis.
Potential therapeutic targets for diseases involving protein mislocalization.