Related Experiment Video
Updated: Jul 16, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Plasma oxytocin levels and anxiety in patients with major depression
G Scantamburlo1, M Hansenne, S Fuchs
1Department of Psychiatry, University of Liège, Psychoneuroendocrinology Unit, CHU of Liège, B35, B-4000 Liège, Belgium. gabrielle.scantamburlo@ulg.ac.be
Abstract:
Cerebrospinal fluid and plasmatic levels of oxytocin (OT) have been found to change in mood disorders. In post-mortem studies, the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased. Moreover, OT is considered as an endogenous antistress hormone. It has also revealed antidepressive effects. OT may contribute to the dysregulation of the HPA system in major depression. The aim of the study was to assess a possible relationship between anxiety and plasma oxytocin (OT) levels in depressive patients. Severity of depression was estimated with the Hamilton Depression Rating Scale and anxiety by using the Spielberger State-Anxiety Inventory. Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r=-0.58, p=0.003) and anxiety (r=-0.61, p=0.005).
Related Concept Videos
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Generalized Anxiety Disorder
Panic Disorder
Neurotransmitters
Depressive Disorders: MDD and Dysthymia
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.