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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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Effects of methamphetamine on response rate: a microstructural analysis.

J Adam Bennett1, Christine E Hughes, Raymond C Pitts

  • 1University of North Carolina Wilmington, NC, USA. james.a.bennett@wmich.edu

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|March 27, 2007
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Methamphetamine affected pigeon key pecking, generally decreasing response rates. Microstructural analysis revealed drug effects on timing not seen in overall rates, suggesting detailed analysis is crucial for understanding drug impacts.

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Area of Science:

  • Behavioral pharmacology
  • Animal behavior

Background:

  • Pigeon key pecking is a model for studying drug effects on operant behavior.
  • Methamphetamine is a psychostimulant with known effects on behavior.

Purpose of the Study:

  • To investigate the effects of methamphetamine on pigeon key pecking under multiple random-interval schedules.
  • To characterize the impact of methamphetamine on both overall response rates and the fine-grained microstructure of responding.

Main Methods:

  • Pigeons were trained on a multiple random-interval (RI) 1-min, RI 4-min schedule.
  • Various doses of methamphetamine (0.3-5.6 mg/kg) were administered.
  • Overall response rates and inter-response times (IRTs) were analyzed.

Main Results:

  • Methamphetamine generally decreased overall response rates in most pigeons.
  • Log-survivor analyses did not yield a consistent pattern across pigeons.
  • IRT analysis showed methamphetamine decreased short IRTs and increased longer IRTs (>2s).

Conclusions:

  • Survivor analyses may not be universally applicable across species for behavioral data.
  • Microstructural analysis of behavior provides insights not apparent from overall rates.
  • Detailed behavioral analysis is more informative than summary measures for characterizing drug effects.