Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis B virus genetic variability and evolution.

Alan Kay1, Fabien Zoulim

  • 1INSERM, U871, Physiopathologie moléculaire et nouveaux traitements des hépatites virales, 151 cours A. Thomas, Lyon F-69424, France. kay@lyon.inserm.fr

Virus Research
|March 27, 2007
PubMed
Summary

Hepatitis B virus (HBV) shows significant genetic diversity due to host interactions and geographic spread. Human interventions like vaccination and antiviral therapies may inadvertently accelerate HBV evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The legacy and future of recurrent neural networks in personalized medicine: A reflection on the 2024 Nobel Physics Prize.

Biomedical journal·2025
Same author

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease.

eGastroenterology·2025
Same author

Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis.

Journal of hepatology·2025
Same author

Opportunities and challenges for hepatitis B cure.

eGastroenterology·2025
Same author

New potent HBV replication inhibitors for the management of chronic hepatitis B are needed.

Nature reviews. Gastroenterology & hepatology·2025
Same author

Liver Enzyme Elevation After Hepatitis C Virus Cure: Is There a Sex Effect? (ANRS CO13 HEPAVIH Cohort).

Journal of viral hepatitis·2025

Area of Science:

  • Virology
  • Evolutionary Biology
  • Hepatology

Background:

  • Hepatitis B virus (HBV) exhibits considerable genetic diversity despite its complex genome.
  • This diversity arises from virus/host interactions and parallel evolution across different regions.

Purpose of the Study:

  • To explore the evolutionary dynamics of Hepatitis B virus.
  • To understand the factors contributing to HBV genetic diversity.
  • To assess the impact of human interventions on HBV evolution.

Main Methods:

  • Analysis of viral genetic sequences.
  • Comparative evolutionary studies.
  • Epidemiological data interpretation.

Main Results:

Related Experiment Videos

  • HBV genetic diversity is shaped by host interactions and geographic factors.
  • Recombination plays a role in HBV evolution.
  • Mass vaccination and antiviral treatments may accelerate HBV evolution.

    • Conclusions:

    • HBV evolution is a complex process influenced by multiple factors.
    • Human interventions, while beneficial for disease control, can exert selective pressures on HBV.
    • Further research is needed to monitor and understand the long-term evolutionary trajectory of HBV under these pressures.